منابع مشابه
Multiple Opiate Receptors
The use of very low concentrations of 1251-[D-Ala2,DLeu5]enkephalin, [3H]naloxone, and [3H]dihydromorphine under similar conditions enables the measurement of different opiate binding sites in a rat brain membrane preparation. In the absence of sodium ions, one such site binds enkephalins and their D-Ala2-substituted analogs with higher affinity than morphine and naloxone (enkephalin receptor),...
متن کاملMyocardial Opiate Receptors
The effect of morphine and niet-enkephaline on the isometric contraction of rabbit papillary muscles was studied. The tested compounds produced a dose-dependent, stereospecific and naloxon-reversible negative inotropic effect indicating the existence of opiate receptors in cardiac muscle. A pretreatment of papillary muscles with the /3-blocking agent atenolol attenuated the negative inotropic a...
متن کاملOpioid receptors: Pinning down the opiate targets
Recent studies of knockout mice conclusively show that the mu opioid receptor mediates the analgesic effects of morphine; they further suggest that the mu opioid receptor also has a role in mediating the effects of other opioid agonists, and provide insights into the non-analgesic effects of mu opioids.
متن کامل14. Opiate Receptors: Isolation and Mechanisms
Research on the mode of action of narcotic analgesic drugs and the mechanism of the development of tolerance and physical dependence is one of the oldest of scientific pursuits. For many years the first step in the action of these drugs was postulated to be their binding to highly specific "receptor" sites. This specific drug-receptor interaction was thought to trigger certain chemical or physi...
متن کاملEvidence for distinct subcellular sites of opiate receptors. Demonstration of opiate receptors in smooth microsomal fractions isolated from rat brain.
We have found opiate receptors enriched in two distinct subcellular fractions obtained from rat brain cellfree homogenates. By several criteria, one fraction contains synaptic plasma membranes, while the other represents predominantly smooth microsomes. Using marker enzyme analysis, we determined that the occurrence of opiate receptors in the smooth microsomal fraction cannot be attributed to ...
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ژورنال
عنوان ژورنال: Anaesthesia
سال: 2007
ISSN: 0003-2409,1365-2044
DOI: 10.1111/j.1365-2044.1993.tb06872.x